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To assess the half maximal inhibitory concentration (IC50) of FOXO4-DRI on the serum limitation-induced senescent fibroblast and the non-senescent control fibroblast, the fibroblast viability in the 2% FBS induced senescent fibroblast and 10% FBS cultured non-senescent control fibroblast with increasing concentrations of FOXO4-DRI was detected, and the cell viability curves were showed in Supplementary Fig

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2017;12(3):e0173722

By using high density DNA methylation array with single CpG site resolution we were able to detect a total 5,484 CpGs plotted in the heatmap reported in Fig

coli 37 , it is possible that these genetic perturbations induce smaller variations in glutathione concentration than are needed to protect against antibiotic lethality resulting from the production of reactive metabolic by-products

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